German English
Charite
Mitarbeiter

Mitarbeiter

Arbeitsgruppenleiter


schließen...

PD Dr. med. Thomas Häupl

Charité - Universitätsmedizin Berlin
Freie Universität und Humboldt Universität Berlin
CharitéCentrum 12 für Innere Medizin und Dermatologie
Medizinische Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie CCM
Forschungslabor - AG Häupl / AG Bioinformatik
Gebäude: Virchowweg 11 (5. Ebene - Raum 009)
Charitéplatz 1
10117 Berlin
Tel: +49(0) 30 450 513 291
Fax: +49(0) 30 450 513 968
thomas.haeupl@charite.de

vcard_thomas_haeupl





1990 - 1993

Graduiertenstipendiat an der Universität Erlangen-Nürnberg in der medizinischen Klinik für Rheumatologie und klinische Immunologie im Graduiertenkolleg "Immunologische Mechanismen der Infektion, Inflammation und Autoimmunität"


1984 - 1990

Studium der Humanmedizin an der Friedrich-Alexander Universität Erlangen-Nürnberg






2006 - ...

Mitgründer und Geschäftsführer der BioRetis GmbH (Nebentätigkeit)


2000 - 2006

Beratende Tätigkeit für TransTissue Technologies GmbH als Leiter für klinische Forschung (Nebentätigkeit)


2000 - ...

Wissenschaftlicher Assistent und Forschungskoordinator an der Medizinische Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie, Charité Universitätsmedizin Berlin


1995 - 2000

Wissenschaftlicher Mitarbeiter an der Medizinische Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie, Charité Universitätsmedizin Berlin


1993 - 1995

Postdoktorand an der Columbia University, Dept. of Pediatrics, Div. of Autoimmunity and Molecular Diseases, gefördert von der Walter-Marget Vereinigung und der DFG; "Differentielle Genexpression bei Synovitis"






2009

Habilitation: "Microarrays zur Erforschung rheumatischer Erkrankungen: Von Einzelmarker zur systemedBiologischen Betrachtung"


1994

Promotion: "Veränderte Immunantwort oder Evasion: die Lyme Borreliose als Modell für chronisch-persistierende Arthritiden"






Gutachtertätigkeiten

  • Arthritis and Rheumatism
  • Annals of the Rheumatic Diseases
  • Rheumatology
  • Arthritis Research and Therapy
  • The Journal of Rheumatology
  • Zeitschrift für Rheumatologie
  • BMC Medical Genomics
  • Osteoarthritis and Cartilage
  • PLoS Biology
  • Tissue Engineering


Aktuelle Forschungsschwerpunkte

  • Genexpressionsanalyse bei rheumatischen Erkrankungen
  • Bioinformatik und Datenbanken für DNA-Array-Analysen
  • Regulatorische Mechanisms der Gelenk-Homöostase
  • Molekulare Wirkungsmechanismen von Immunsuppressiva
  • Mesenchymale Stammzellen, Gewebedifferenzierung und regenerative Therapieansätze





2016

Strehl C, Schellmann S, Maurizi L, Hofmann-Amtenbrink M, Häupl T, Hofmann H, Buttgereit F, Gaber T. Effects of PVA-coated nanoparticles on human T helper cell activity. Toxicol Lett. (2016) PMID: 26774940


2015

Haymerle G, Schneider S, Harris L, Häupl T, Schopper C, Pammer J, Grasl MC, Erovic BM. Minor salivary gland carcinoma: a review of 35 cases. Eur Arch Otorhinolaryngol. (2015) PMID: 26498950

Stuhlmüller B, Skriner K, Häupl T. Biomarkers for prognosis of response to anti-TNF therapy of rheumatoid arthritis : Where do we stand? Z Rheumatol. (2015) PMID: 26347122

Strehl C, Gaber T, Maurizi L, Hahne M, Rauch R, Hoff P, Häupl T, Hofmann-Amtenbrink M, Poole AR, Hofmann H, Buttgereit F. Effects of PVA coated nanoparticles on human immune cells. Int J Nanomedicine. (2015) PMID: 26056442

Sörensen T, Baumgart S, Durek P, Grützkau A, Häupl T. immunoClust-An automated analysis pipeline for the identification of immunophenotypic signatures in high-dimensional cytometric datasets. Cytometry A. (2015) PMID: 25850678

Smiljanovic B, Stuhlmüller B, Bonin M, Pade S, Backhaus B, Burmester GR, Radbruch A, Grützkau A, Häupl T. The synovial tissue transcriptome reveals combinations of protein biomarkers for unambiguous identification of RA patients from synovial fluid and for quantification of disease activity in serum. Ann Rheum Dis. (2015) Link


2014

Haftmann C, Stittrich AB, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz GA, Riedel R, Siede J, Lehmann K, Weinberger EE, Zimmel D, Lauer U, Häupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grün JR, Baumgrass R, Matz M, Löhning M, Scheffold A, Wittmann J, Chang HD, Rajewsky N, Jäck HM, Radbruch A, Mashreghi MF. miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim. Eur J Immunol. (2014) PMID: 25486906

Häupl T, Zimmermann M, Kalus U, Yürek S, Koscielny J, Hoppe B. Angiotensin converting enzyme intron 16 insertion/deletion genotype is associated with plasma C-reactive protein concentration in uteroplacental dysfunction. J Renin Angiotensin Aldosterone Syst. (2014) PMID: 25155623

Ghannam K, Martinez-Gamboa L, Spengler L, Krause S, Smiljanovic B, Bonin M, Bhattarai S, Grützkau A, Burmester GR, Häupl T, Feist E. Upregulation of Immunoproteasome Subunits in Myositis Indicates Active Inflammation with Involvement of Antigen Presenting Cells, CD8 T-Cells and IFNγ. PLoS One (2014) PMID: 25098831

Kupfer P, Huber R, Weber M, Vlaic S, Häupl T, Koczan D, Guthke R, Kinne RW. Novel application of multi-stimuli network inference to synovial fibroblasts of rheumatoid arthritis patients. BMC Med Genomics (2014) PMID: 24989895

Woetzel D, Huber R, Kupfer P, Pohlers D, Pfaff M, Driesch D, Häupl T, Koczan D, Stiehl P, Guthke R, Kinne RW. Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation. Arthritis Res Ther. (2014) PMID: 24690414

Stuhlmüller B, Häupl T, Burmester GR, Kinne RW. Prerequisites to Define and to Validate Therapy-Predicitive Blood Biomarkers. (2014) Link

Bonin M, Kokatjuhha J, Mans K, Grützkau A, Smiljanovic B, Sörensen T, Häupl T. Identification of geneexpression networks in different immunological states. Ann Rheum Dis. (2014) Link

Bonin M, Weidel L, Schendel P, Mans K, Flemming S, Grützkau A, Smiljanovic B, Sörensen T, Günther S, Häupl T. BioConPages - Comparison of DNA methylation and gene expression in different immune cells. Ann Rheum Dis. (2014) Link

Smiljanovic B, Stuhlmüller B, Maslinski W, Vogl T, Pade S, Backhaus M, Burmester GR, Radbruch A, Grützkau A, Häupl T. From tissue- and cell-specific transcriptomes to candidate markers in rheumatoud arthritis. Ann Rheum Dis. (2014) Link

Ghannam K, Martinez-Gamboa L, Spengler L, Krause S, Smiljanovic B, Bonin M, Grützkau A, Burmester GR, Häupl T, Feist E. OP0131 Upregulation of Immunoproteasome Subunits PSMB8 and PSMB9 in Myositis Indicates Active Inflammation with Involvement of Antigen Presenting Cells, CD8+ T-Cells and IFN Gamma. Ann Rheum Dis. (2014) Link

Duroux-Richard I, Roubert C, Ammari M, Présumey J, Grün J, Häupl T, Grützkau A, Lecellier CH, Jorgensen C, Apparailly F. MIR-125B controls mitochondrial functions and dynamics in monocytes. Ann Rheum Dis. (2014) Link

Kyogoku C, Smiljanovic B, Grün J, Schulte-Wrede U, Alexander T, Biesen R, Hiepe F, Häupl T, Radbruch A, Grützkau A. T helper lymphocytes and monocytes as biosensors of type I interferon responses in viral infection and autoimmunity. Ann Rheum Dis. (2014) Link


2013

Kyogoku C, Smiljanovic B, Grün JR, Biesen R, Schulte-Wrede U, Häupl T, Hiepe F, Alexander T, Radbruch A, Grützkau A. Cell-specific type I IFN signatures in autoimmunity and viral infection: what makes the difference? PLoS One. (2013) PMID: 24391825

Ullah M, Stich S, Häupl T, Eucker J, Sittinger M, Ringe J. Reverse differentiation as a gene filtering tool in genome expression profiling of adipogenesis for fat marker gene selection and their analysis. PLoS One. (2013) PMID: 23922792

Cobb JE, Plant D, Flynn E, Tadjeddine M, Dieudé P, Cornélis F, Arlestig L, Dahlqvist SR, Goulielmos G, Boumpas DT, Sidiropoulos P, Krintel SB, Ornbjerg LM, Hetland ML, Klareskog L, Häupl T, Filer A, Buckley CD, Raza K, Witte T, Schmidt RE, Fitzgerald O, Veale D, Eyre S, Worthington J. Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans. PLoS One. (2013) PMID: 23840476

Stuhlmüller B, Feist E, Häupl T, Burmester GR, Pipitone N. New aspects on the pathogenesis of myositis. Z Rheumatol. (2013) PMID: 23515563

Weix J, Häupl T, Raio L, Villiger PM, Förger F. The physiologic increase in expression of some type I IFN-inducible genes during pregnancy is not associated with improved disease activity in pregnant patients with rheumatoid arthritis. Transl Res. (2013) PMID: 23507374

Bonin M, Flemming S, Günther S, Grützkau A, Häupl T. Combined Analysis of Epigenetic and Transcriptional Profiles in Different Immune Cells Identifies Hot Spots of Gene Regulation by DNA Methylation. Ann Rheum Dis. (2013) Link

Häupl T, Sörensen T, Smiljanovic B, Bonin M, Grützkau A, Nikolaou C, Pandis I, Kollias G, Rowe A. Comparative Transcriptome Analysis of Human and Mouse Synovial Fibroblast Responses to TNF. Ann Rheum Dis. (2013) Link

Smiljanovic B, Stuhlmüller B, Pade S, Backhaus M, Burmester GR, Radbruch A, Grützkau A, Häupl T. Synovial Tissue Transcriptome and Synovial Fluid Proteome have Stronger Discriminatory Power than Serum in Dissecting Inflammation in RA. Ann Rheum Dis. (2013) Link

Sörensen T, Schulte-Wrede U, Pade S, Hirseland H, Burmester GR, Radbruch A, Grützkau A, Häupl T. Automated and Standardised Analysis for High Dimensional Cytometric Data Provides New Options for Complex Cell-Associated Biomarker Screening. Ann Rheum Dis. (2013) Link

Kyogoku C, Smiljanovic B, Grün JR, Alexander T, Biesen R, Hiepe F, Häupl T, Radbruch A, Grützkau A. Cell-specific type I Interferon signatures in autoimmunity and viral infection: what makes the difference?. Ann Rheum Dis. (2013) Link

Smiljanovic B, Stuhlmüller B, Maslinski W, Burmester GR, Radbruch A, Grützkau A, Häupl T. Dissecting disease-specific differences in RA and OA by transcriptome analyses of synovial tissue, blood and bone marrow monocytes. Ann Rheum Dis. (2013) Link

Scherer HU, Burmester GR, Häupl T. Biomarkers and personalized medicine. Z Rheumatol. (2013) PMID: 23223890


2012

Hassert R, Pagel M, Ming Z, Häupl T, Abel B, Braun K, Wiessler M, Beck-Sickinger AG. Biocompatible Silicon Surfaces through Orthogonal Click Chemistries and a High Affinity Silicon Oxide Binding Peptide. Bioconjug Chem. (2012) PMID: 22989005

Smiljanovic B, Grün JR, Biesen R, Schulte-Wrede U, Baumgrass R, Stuhlmüller B, Maslinski W, Hiepe F, Burmester GR, Radbruch A, Häupl T, Grützkau A. The multifaceted balance of TNF-α and type I/II interferon responses in SLE and RA: how monocytes manage the impact of cytokines. J Mol Med. (2012) PMID: 22610275

Häupl T, Appel H, Backhaus M, Burkhardt H, Grünke M, Grützkau A, Hoppe B, Listing J, Ostendorf B, Rudwaleit M, Sieper J, Skapenko A, Skriner K, Sörensen T, Stuhlmüller B, Zink A, Schulze-Koops H, Burmester GR. Biomarkers in rheumatology: Biomarkers and imaging for the diagnosis and stratification of rheumatoid arthritis and spondylarthritis in the ArthroMark network funded by the Federal Ministry of Education and Research. Z Rheumatol. (2012) PMID: 22546912

Kruger JP, Endres M, Neumann K, Stuhlmuller B, Morawietz L, Häupl T, Kaps C. Chondrogenic differentiation of human subchondral progenitor cells is affected by synovial fluid from donors with osteoarthritis or rheumatoid arthritis. J Orthop Surg Res. (2012) PMID: 22414301

Jullien N, Maudinet A, Leloutre B, Ringe J, Häupl T, Marie PJ. Downregulation of ErbB3 By Wnt3a Contributes to Wnt-induced osteoblast differentiation in mesenchymal cells. J Cell Biochem. (2012) PMID: 22274864

Hoppe B, Häupl T, Skapenko A, Ziemer S, Tauber R, Salama A, Schulze-Koops H, Burmester GR, Dörner T. Fibrinogen and factor XIII A-subunit genotypes interactively influence C-reactive protein levels during inflammation. Ann Rheum Dis. (2012) PMID: 22267327

Weix J, Förger F, Häupl T, Surbek D, Ostensen M, Villiger PM. Influence of pregnancy on the adipocytokine and PPAR pathways in peripheral blood mononuclear cells of healthy donors and RA patients. Arthritis Rheum. (2012) PMID: 22231457


2011

Hoppe B, Burmester GR, Häupl T. Prothrombin 20210G>A genotype and C-reactive protein level. Blood. (2011) PMID: 22021457

Biesen R, Häupl T. DNA Microarrays. Z Rheumatol. (2011) PMID: 21956826

Menssen A, Häupl T, Sittinger M, Delorme B, Charbord P, Ringe J. Differential gene expression profiling of human bone marrow-derived mesenchymal stem cells during adipogenic development. BMC Genomics (2011) PMID: 21943323

Bal G, Kamhieh-Milz J, Futschik M, Häupl T, Salama A, Moldenhauer A. Transcriptional profiling of the hematopoietic support of interleukin-stimulated human umbilical vein endothelial cells (HUVECs). Cell Transplant. (2011) PMID: 21669038

Scheel T, Gursche A, Zacher J, Häupl T, Berek C. V-region gene analysis of locally defined synovial B and plasma cells reveals selected B cell expansion and accumulation of plasma cell clones in rheumatoid arthritis. Arthritis Rheum. (2011) PMID: 20882667


2010

Shahab-Osterloh S, Witte F, Hoffmann A, Winkel A, Laggies S, Neumann B, Seiffart V, Lindenmaier W, Gruber AD, Ringe J, Häupl T, Thorey F, Willbold E, Corbeau P, Gross G. Mesenchymal stem cell-dependent formation of heterotopic tendon-bone insertions (osteotendinous junctions). Stem Cells. (2010) PMID: 20882636

Slansky E, Li J, Häupl T, Morawietz L, Krenn V, Pessler F. Quantitative determination of the diagnostic accuracy of the synovitis score and its components. Histopathology. (2010) PMID: 20840673

Endres M, Andreas K, Kalwitz G, Freymann U, Neumann K, Ringe J, Sittinger M, Häupl T, Kaps C. Chemokine profile of synovial fluid from normal, osteoarthritis and rheumatoid arthritis patients: CCL25, CXCL10 and XCL1 recruit human subchondral mesenchymal progenitor cells. Osteoarthritis Cartilage. (2010) PMID: 20709179

Smiljanovic B, Grün JR, Steinbrich-Zöllner M, Stuhlmüller B, Häupl T, Burmester GR, Radbruch A, Grützkau A, Baumgrass R. Defining TNF-α- and LPS-induced gene signatures in monocytes to unravel the complexity of peripheral blood transcriptomes in health and disease. J Mol Med. (2010) PMID: 20640394

Kaltz N, Ringe J, Holzwarth C, Charbord P, Niemeyer M, Jacobs VR, Peschel C, Häupl T, Oostendorp RA. Novel markers of mesenchymal stem cells defined by genome-wide gene expression analysis of stromal cells from different sources. Exp Cell Res. (2010) PMID: 20599957

Hamidouche Z, Fromigué O, Ringe J, Häupl T, Marie PJ. Crosstalks between integrin alpha 5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation. BMC Cell Biol. (2010) PMID: 20573191

Göhring AR, Lübke C, Andreas K, Kaps C, Häupl T, Pruss A, Perka C, Sittinger M, Ringe J: Tissue-engineered cartilage of porcine and human origin as in vitro test system in arthritis research: Biotechnol Prog. (2010) PMID: 20306542

Charbord P, Livne E, Gross G, Häupl T, Neves NM, Marie P, Bianco P, Jorgensen C: Human Bone Marrow Mesenchymal Stem Cells: A Systematic Reappraisal Via the Genostem Experience: Stem Cell Rev. (2010) PMID: 20198518

Scherer HU, van der Woude D, Ioan-Facsinay A, El Bannoudi H, Trouw LA, Koeleman CA, Wang J, Häupl T, Burmester GR, Deelder AM, Huizinga TW, Wuhrer M, Toes RE: Glycan profiling of anti-citrullinated protein antibodies (ACPA) isolated from human serum and synovial fluid: Arthritis Rheum. (2010) PMID: 20178128

Miraoui H, Ringe J, Häupl T, Marie PJ: Increased EFG- and PDGFalpha-receptor signaling by mutant FGF-receptor 2 contributes to osteoblast dysfunction in Apert craniosynostosis: Hum Mol Genet. (2010) PMID: 20124286

Häupl T, Stuhlmüller B, Grützkau A, Radbruch A, Burmester GR: Does gene expression analysis inform us in rheumatoid arthritis?: Ann Rheum Dis. (2010) PMID: 19995742

Stuhlmüller B, Häupl T, Hernandez MM, Grützkau A, Kuban RJ, Tandon N, Voss JW, Salfeld J, Kinne RW, Burmester GR: CD11c as a transcriptional biomarker to predict response to anti-TNF monotherapy with adalimumab in patients with rheumatoid arthritis: Clin Pharmacol Ther. (2010) PMID: 20032971


2009

Krüger JP, Endres M, Neumann K, Häupl T, Erggelet C, Kaps C: Chondrogenic differentiation of human subchondral progenitor cells is impaired by rheumatoid arthritis synovial fluid: J Orthop Res. (2009) PMID: 20041492

Feron F, Delorme B, Nivet E, Gaillard J, Häupl T, Ringe J, Deveze A, Magnan J, Sohier J, Khrestchatisky M, Roman F, Charbord P, Sensebé L, Layrolle P: The human nose harbours a niche of olfactory ecto-mesenchymal stem cells displaying neurogenic and osteogenic properties: Stem Cells Dev. (2009) PMID: 19905894

Gaber T, Häupl T, Sandig G, Tykwinska K, Fangradt M, Tschirschmann M, Hahne M, Dziurla R, Erekul K, Lautenbach M, Kolar P, Burmester GR, Buttgereit F: Adaptation of human CD4+ T cells to pathophysiological hypoxia: a transcriptome analysis: J Rheumatol. (2009) PMID: 19884271

Hamidouche Z, Fromigué O, Ringe J, Häupl T, Vaudin P, Pagès JC, Srouji S, Livne E, Marie PJ: Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis: Proc Natl Acad Sci USA. (2009) PMID: 19843692

Jakobs M, Häupl T, Krenn V, Guenther R: MMP- and FAP-mediated non-inflammation-related destruction of cartilage and bone in rheumatoid arthritis: Z Rheumatol. (2009) PMID: 19593575

Delorme B, Ringe J, Pontikoglou C, Gaillard J, Langonné A, Sensebé L, Noël D, Jorgensen C, Häupl T, Charbord P: Specific lineage-priming of bone marrow mesenchymal stem cells provides the molecular framework for their plasticity: Stem Cells. (2009) PMID: 19418444

Stich S, Haag M, Häupl T, Sezer O, Notter M, Kaps C, Sittinger M, Ringe J: Gene expression profiling of human mesenchymal stem cells chemotactically induced with CXCL12: Cell Tissue Res. (2009) PMID: 19296133

Menssen A, Edinger G, Grün JR, Haase U, Baumgrass R, Grützkau A, Radbruch A, Burmester GR, Häupl T: SiPaGene: A new repository for instant online retrieval, sharing and meta-analyses of GeneChip expression data: BMC Genomics. (2009) PMID: 19265543

Mrugala D, Dossat N, Ringe J, Delorme B, Coffy A, Bony C, Charbord P, Häupl T, Daures JP, Noël D, Jorgensen C: Gene expression profile of multipotent mesenchymal stromal cells: Identification of pathways common to TGFbeta3/BMP2-induced chondrogenesis: Cloning Stem Cells. (2009) PMID: 19196040

Andreas K, Häupl T, Lübke C, Ringe J, Morawietz L, Wachtel A, Sittinger M, Kaps C: Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration: Arthritis Res Ther. (2009) PMID: 19192274

Kalwitz G, Endres M, Neumann K, Skriner K, Ringe J, Sezer O, Sittinger M, Häupl T, Kaps C: Gene expression profile of adult human bone marrow-derived mesenchymal stem cells stimulated by the chemokine CXCL7: Int J Biochem Cell Biol. (2009) PMID: 18707017

Hoppe B, Häupl T, Egerer K, Gruber R, Kiesewetter H, Salama A, Burmester GR, Dörner T: Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis: Ann Rheum Dis. (2009) PMID: 18633125


2008

Bramlage CP, Kaps C, Ungethüm U, Bramlage P, Koziolek M, Wessels J, Krenn V, Pruss A, Müller GA, Strutz F, Burmester GR, Häupl T: Modulatory effects of inflammation and therapy on GDF-5 expression in rheumatoid arthritis synovium: Scand J Rheumatol. (2008) PMID: 18830904

Häupl T, Østensen M, Grützkau A, Radbruch A, Burmester GR, Villiger PM: Reactivation of rheumatoid arthritis after pregnancy: increased phagocyte and recurring lymphocyte gene activity: Arthritis Rheum. (2008) PMID: 18821679

Niesner U, Albrecht I, Janke M, Doebis C, Loddenkemper C, Lexberg MH, Eulenburg K, Kreher S, Koeck J, Baumgrass R, Bonhagen K, Kamradt T, Enghard P, Humrich JY, Rutz S, Schulze-Topphoff U, Aktas O, Bartfeld S, Radbruch H, Hegazy AN, Löhning M, Baumgart DC, Duchmann R, Rudwaleit M, Häupl T, Gitelman I, Krenn V, Gruen J, Sieper J, Zeitz M, Wiedenmann B, Zipp F, Hamann A, Janitz M, Scheffold A, Burmester GR, Chang HD, Radbruch A: Autoregulation of Th1-mediated inflammation by twist1: J Exp Med. (2008) PMID: 18663125

Kaltz N, Funari A, Hippauf S, Delorme B, Noël D, Riminucci M, Jacobs VR, Häupl T, Jorgensen C, Charbord P, Peschel C, Bianco P, Oostendorp RA: In vivo osteoprogenitor potency of human stromal cells from different tissues does not correlate with expression of POU5F1 or its pseudogenes: Stem Cells. (2008) PMID: 18617685

Häupl T, Østensen M, Grützkau A, Burmester GR, Villiger PM: Interaction between rheumatoid arthritis and pregnancy: correlation of molecular data with clinical disease activity measures: Rheumatology (Oxford). (2008) PMID: 18504279

Tripmacher R, Gaber T, Dziurla R, Häupl T, Erekul K, Grützkau A, Tschirschmann M, Scheffold A, Radbruch A, Burmester GR, Buttgereit F: Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production: Eur J Immunol. (2008) PMID: 18493983

Ringe J, Leinhase I, Stich S, Loch A, Neumann K, Haisch A, Häupl T, Manz R, Kaps C, Sittinger M: Human mastoid periosteum-derived stem cells: promising candidates for skeletal tissue engineering: J Tissue Eng Regen Med. (2008) PMID: 18383554

Biesen R, Demir C, Barkhudarova F, Grün JR, Steinbrich-Zöllner M, Backhaus M, Häupl T, Rudwaleit M, Riemekasten G, Radbruch A, Hiepe F, Burmester GR, Grützkau A: Sialic acid-binding Ig-like lectin 1 expression in inflammatory and resident monocytes is a potential biomarker for monitoring disease activity and success of therapy in systemic lupus erythematosus: Arthritis Rheum. (2008) PMID: 18383365

Guenther R, Krenn V, Häupl T: Expression analyses for rheumatoid arthritis: Z Rheumatol. (2008) PMID: 18210133

Andreas K, Lübke C, Häupl T, Dehne T, Morawietz L, Ringe J, Kaps C, Sittinger M: Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study: Arthritis Res Ther. (2008) PMID: 18205922

Delorme B, Ringe J, Gallay N, Le Vern Y, Kerboeuf D, Jorgensen C, Rosset P, Sensebé L, Layrolle P, Häupl T, Charbord P: Specific plasma membrane protein phenotype of culture-amplified and native human bone marrow mesenchymal stem cells: Blood. (2008) PMID: 18086871

Kastrinaki MC, Sidiropoulos P, Roche S, Ringe J, Lehmann S, Kritikos H, Vlahava VM, Delorme B, Eliopoulos GD, Jorgensen C, Charbord P, Häupl T, Boumpas DT, Papadaki HA: Functional, molecular and proteomic characterisation of bone marrow mesenchymal stem cells in rheumatoid arthritis: Ann Rheum Dis. (2008) PMID: 17921184


2007

Grützkau A, Grün J, Häupl T, Burmester GR, Radbruch A: Gene expression in inflammatory rheumatic diseases: Dtsch Med Wochenschr. (2007) PMID: 17823881

Endres M, Neumann K, Häupl T, Erggelet C, Ringe J, Sittinger M, Kaps C: Synovial fluid recruits human mesenchymal progenitors from subchondral spongious bone marrow: J Orthop Res. (2007) PMID: 17549723

Häupl T, Burmester GR, Giannitsis E, Rohrlach T, Spanuth E, Parsch H, Brune K: N-terminal prohormone brain natriuretic peptide: a biomarker for detecting cardiovascular risks in patients with rheumatoid arthritis or osteoarthritis: Ann Rheum Dis. (2007) PMID: 17513573

Neumann K, Endres M, Ringe J, Flath B, Manz R, Häupl T, Sittinger M, Kaps C: BMP7 promotes adipogenic but not osteo-/chondrogenic differentiation of adult human bone marrow-derived stem cells in high-density micro-mass culture: J Cell Biochem. (2007) PMID: 17497692

Häupl T, Yahyawi M, Lübke C, Ringe J, Rohrlach T, Burmester GR, Sittinger M, Kaps C: Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs: J Biomol Screen. (2007) PMID: 17379860

Ringe J, Häupl T, Sittinger M: Future of tissue engineering in rheumatic diseases: Expert Opin Biol Ther. (2007) PMID: 17309320


2006

Krenn V, Morawietz L, Burmester GR, Kinne RW, Mueller-Ladner U, Muller B, Häupl T: Synovitis score: discrimination between chronic low-grade and high-grade synovitis: Histopathology. (2006) PMID: 16978198

Krenn V, Morawietz L, König B, Otto M, Kriegsmann J, Köpenik A, Böhme T, Häupl T: Low-grade-/high-grade-synovitis: synovitis-score as a gold standard?: Orthopade. (2006) PMID: 16819616

Mahr S, Burmester GR, Hilke D, Göbel U, Grützkau A, Häupl T, Hauschild M, Koczan D, Krenn V, Neidel J, Perka C, Radbruch A, Thiesen HJ, Müller B: Cis- and trans-acting gene regulation is associated with osteoarthritis: Am J Hum Genet. (2006) PMID: 16642435

Kaps C, Frauenschuh S, Endres M, Ringe J, Haisch A, Lauber J, Buer J, Krenn V, Häupl T, Burmester GR, Sittinger M: Gene expression profiling of human articular cartilage grafts generated by tissue engineering: Biomaterials. (2006) PMID: 16545449

Bramlage CP, Häupl T, Kaps C, Ungethüm U, Krenn V, Pruss A, Müller GA, Strutz F, Burmester GR: Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis: Arthritis Res Ther. (2006) PMID: 16542506

Hoppe B, Häupl T, Gruber R, Kiesewetter H, Burmester GR, Salama A, Dörner T: Detailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis: a case-control study: Arthritis Res Ther. (2006) PMID: 16469113


2005

Djouad F, Bony C, Häupl T, Uzé G, Lahlou N, Louis-Plence P, Apparailly F, Canovas F, Rème T, Sany J, Jorgensen C, Noël D: Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells: Arthritis Res Ther. (2005) PMID: 16277684

Bramlage CP, Häupl T, Kaps C, Bramlage P, Müller GA, Strutz F: Bone morphogenetic proteins in the skeletal system: Z Rheumatol. (2005) PMID: 16184350

Krenn V, Morawietz L, Burmester GR, Häupl T: Synovialitis score: histopathological grading system for chronic rheumatic and non-rheumatic synovialitis: Z Rheumatol. (2005) PMID: 15965818


2004

Burmester GR, Häupl T: Strategies using functional genomics in rheumatic diseases: Autoimmun Rev. (2004) PMID: 15546803

Kaps C, Hoffmann A, Zilberman Y, Pelled G, Häupl T, Sittinger M, Burmester G, Gazit D, Gross G: Distinct roles of BMP receptors Type IA and IB in osteo-/chondrogenic differentiation in mesenchymal progenitors (C3H10T1/2): Biofactors. (2004) PMID: 15322331

Krenn V, Petersen I, Häupl T, Koepenik A, Blind C, Dietel M, Konthur Z, Skriner K: Array technology and proteomics in autoimmune diseases: Pathol Res Pract. (2004) PMID: 15237918

Häupl T, Krenn V, Stuhlmüller B, Radbruch A, Burmester GR: Perspectives and limitations of gene expression profiling in rheumatology: new molecular strategies: Arthritis Res Ther. (2004) PMID: 15225356

Sopov I, Sörensen T, Magbagbeolu M, Jansen L, Beer K, Kühne-Heid R, Kirchmayr R, Schneider A, Dürst M: Detection of cancer-related gene expression profiles in severe cervical neoplasia: Int J Cancer. (2004) PMID: 15305373


2003

Ringe J, Häupl T, Sittinger M: Mesenchymal stem cells for tissue engineering of bone and cartilage: Med Klin (Munich). (2003) PMID: 14992201

Schmitt B, Ringe J, Häupl T, Notter M, Manz R, Burmester GR, Sittinger M, Kaps C: BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture: Differentiation. (2003) PMID: 14686954

Häupl T, Ringe J, Erggelet C, Kaps C, Burmester GR, Sittinger M: Tissue engineering: chances and challenges for application in rheumatic diseases: Z Rheumatol. (2003) PMID: 14648092


2002

Häupl T, Burmester GR, Stuhlmüller B: New aspects of molecular biology diagnosis. Array technology and expression profile for characterization of rheumatic diseases: Z Rheumatol. (2002) PMID: 12426845

Kaps C, Loch A, Haisch A, Smolian H, Burmester GR, Häupl T, Sittinger M: Human platelet supernatant promotes proliferation but not differentiation of articular chondrocytes: Med Biol Eng Comput. (2002) PMID: 12227637

Krenn V, Morawietz L, Häupl T, Neidel J, Petersen I, König A: Grading of chronic synovitis--a histopathological grading system for molecular and diagnostic pathology: Pathol Res Pract. (2002) PMID: 12092767

Riemekasten G, Ziemer S, Häupl T, Melzer C, Loddenkemper K, Hauptmann S, Burmester GR, Hiepe F: Shwartzman phenomenon in a patient with active systemic lupus erythematosus preceding fatal disseminated intravascular coagulation: Lupus. (2002) PMID: 12043882

Ringe J, Kaps C, Schmitt B, Büscher K, Bartel J, Smolian H, Schultz O, Burmester GR, Häupl T, Sittinger M: Porcine mesenchymal stem cells. Induction of distinct mesenchymal cell lineages: Cell Tissue Res. (2002) PMID: 11904768

Kaps C, Bramlage C, Smolian H, Haisch A, Ungethüm U, Burmester GR, Sittinger M, Gross G, Häupl T: Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction: Arthritis Rheum. (2002) PMID: 11817587


2000

Rosen O, Thiel A, Massenkeil G, Hiepe F, Häupl T, Radtke H, Burmester GR, Gromnica-Ihle E, Radbruch A, Arnold R: Autologous stem-cell transplantation in refractory autoimmune diseases after in vivo immunoablation and ex vivo depletion of mononuclear cells: Arthritis Res. (2000) PMID: 11056673


1999

Sittinger M, Perka C, Schultz O, Häupl T, Burmester GR: Joint cartilage regeneration by tissue engineering: Z Rheumatol. (1999) PMID: 10441839

Redlich A, Perka C, Schultz O, Spitzer R, Häupl T, Burmester GR, Sittinger M: Bone engineering on the basis of periosteal cells cultured in polymer fleeces: J Mater Sci Mater Med. (1999) PMID: 15347948


1998

Riemekasten G, Marell J, Trebeljahr G, Klein R, Hausdorf G, Häupl T, Schneider-Mergener J, Burmester GR, Hiepe F: A novel epitope on the C-terminus of SmD1 is recognized by the majority of sera from patients with systemic lupus erythematosus: J Clin Invest. (1998) PMID: 9710444

Keyszer G, Redlich A, Häupl T, Zacher J, Sparmann M, Engethüm U, Gay S, Burmester GR: Differential expression of cathepsins B and L compared with matrix metalloproteinases and their respective inhibitors in rheumatoid arthritis and osteoarthritis: a parallel investigation by semiquantitative reverse transcriptase-polymerase chain reaction and immunohistochemistry: Arthritis Rheum. (1998) PMID: 9704635

Seki T, Selby J, Häupl T, Winchester R: Use of differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes: Arthritis Rheum. (1998) PMID: 9704633


1997

Häupl T, Landgraf S, Netusil P, Biller N, Capiau C, Desmons P, Hauser P, Burmester GR: Activation of monocytes by three OspA vaccine candidates: lipoprotein OspA is a potent stimulator of monokines: FEMS Immunol Med Microbiol. (1997) PMID: 9322065


1994

Rittig MG, Häupl T, Krause A, Kressel M, Groscurth P, Burmester GR: Borrelia burgdorferi-induced ultrastructural alterations in human phagocytes: a clue to pathogenicity?: J Pathol. (1994) PMID: 7931847

Rittig MG, Häupl T, Burmester GR: Coiling phagocytosis: a way for MHC class I presentation of bacterial antigens?: Int Arch Allergy Immunol. (1994) PMID: 8260849


1993

Häupl T, Hahn G, Rittig M, Krause A, Schoerner C, Schönherr U, Kalden JR, Burmester GR: Persistence of Borrelia burgdorferi in ligamentous tissue from a patient with chronic Lyme borreliosis: Arthritis Rheum. (1993) PMID: 8240439


1992

Rittig MG, Krause A, Häupl T, Schaible UE, Modolell M, Kramer MD, Lütjen-Drecoll E, Simon MM, Burmester GR: Coiling phagocytosis is the preferential phagocytic mechanism for Borrelia burgdorferi: Infect Immun. (1992) PMID: 1398932

Häupl T, Burmester GR: Clinical aspects, diagnosis and therapy of Lyme borreliosis: Z Arztl Fortbild (Jena). (1992) PMID: 1546489


1989

Häupl T, Burmester GR, Hahn G, Feige U, Rordorf-Adam C, Kalden JR: Differential immunological response of patients with rheumatoid arthritis towards two different Epstein-Barr virus strains: inhibition of interleukin-1 release by the B95-8, but not the P3HR-1 virus strain: Rheumatol Int. (1989) PMID: 2558410

Patente

Inventor: Stuhlmüller B, Häupl T: A composition of nucleic acid sequences, specific for in inflammatory disease, in particular rheumatoid arthritis submission no.: EP05026588, submission date: 18.12.2005.

Inventor: Häupl T, Grün J, Radbruch A, Burmester GR, Kaps C, Grützkau A: Verfahren zur Erkennung von Signaturen in komplexen Genexpressionsprofilen: submission no.: DE102004016437A1, submission date: 04.04.2004, publication date: 20.10.2005.

Inventor: Häupl T, Grün J, Radbruch A, Burmester GR, Kaps C, Grützkau A: Methods for recoginzing signatures in complex profiling: submission no.: EP000001733050A2, submission date: 04.04.2005, publication date: 20.10.2005.

Inventor: Stuhlmüller B, Häupl T, Kiesslich O, Burmester GR: Nucleic acid microarray for diagnosis of rheumatoid arthritis and prognosis of anti-TNF alpha therapy: submission no.: PCT/WO03/01822, publication date: 05.07.2005.

Inventor: Stuhlmüller B, Häupl T: Nucleic acid array comprising selective monocytic/macrophagic genes: submission no.: EP000001523575A1M, publication date: 20.04.2004.

Inventor: Stuhlmüller B, Häupl T, Kiesslich O, Burmester GR: Nukleinsäurearray zur Diagnose der Rheumatoiden Arthritis und Prognose der anti-TNF-alpha Therapie: submission no: DE10243524, publication date: 12.02.2004.

Inventor: Stuhlmüller B, Häupl T: Nucleic acid microarray for diagnosis of rheumatoid arthritis and prognosis of anti-TNF-alpha therapy: submission no. / PCT no.: (WO)PCT/DE03/01822, submission date: 21.07.2003.

Inventor: Stuhlmüller B, Häupl T, Kiesslich O, Burmester GR: Nucleic acid array comprising selective monocytic macrophagic genes: submission no.: AU002003285285A1, publication date: 28.05.2003.

Inventor: Stuhlmüller B, Häupl T: Nukleinsäure-Array: submission no.: DE10155600, publication date: 22.05.2003.

Inventor: Stuhlmüller B, Häupl T, Kiesslich O, Burmester GR: Nukleinsäurearray zur Diagnose der Rheumatoiden Arthritis und Prognose der anti-TNF-alpha Therapie: submission no.: DE10243524, submission date: 24.07.2002.






10.2013

Stem cell-dependent therapies
Gerhard Gross, Thomas Häupl (Eds.)
Mesenchymal Stem Cells in Chronic Inflammatory Disorders
http://www.degruyter.com